SAN DIEGO and CHENGDU, China, Sept. 15, 2021 (GLOBE NEWSWIRE) -- Biosplice Therapeutics, Inc. ("Biosplice"), a clinical-stage biotechnology company pioneering therapeutics based on CLK/DYRK . Feb 2019 - Jan 20212 years. Get stock recommendations, portfolio guidance, and more from The Motley Fool's premium services. Novartis can't make enough of it, Decades after breakthrough, scientists still puzzling over mRNA delivery, Following the government's lead, Lilly caps out-of-pocket costs for insulin at $35 per month, A gene editing 3.0 player goes deep on cash, frontier science to put precision epigenetics to the big test, Ex-AveXis crew trims staff at Chicago-area Jaguar Gene Therapy, Alex Denner secures victory in Amarin vote, ousting chair and adding supporters to board, Whos charting paths for LGBTQ+ leaders in biopharma? Buy or sell Biosplice Therapeutics stock Learn more about Biosplice Therapeutics IPO Register for Details Biosplice has over 80 publications in journals and as conference presentations. Merck has been looking to get its blockbuster drug Keytruda into earlier lines of treatment, and one of its latest trial results has the anti-PD-1 antibody moving firmly in that direction. AT-GAA consists of biologic cipaglucosidase alfaand miglustat, a stabilizer of the biologic. By Alex Keown. When he told a group of senior scientists about his ideas for drug delivery at a Chinese restaurant in 1979, one of them blew cigar smoke in his face. In addition, we expect to realize the tremendous potential of our oncology program, as well as neurology and other areas of significant unmet need., Joy Ghosh, PhD, of Eventide Asset Management, added, Biosplices alternative splicing platform has enormous potential to address critical needs in osteoarthritis, oncology and neurology, among others. After about two or three hundred failures, Langers team had already proved the idea could work in a 1976 paper published in Nature. Merck revealed on Wednesday that a Phase III trial investigating Keytruda for patients with stage II, IIIA or IIIB non-small cell lung cancer hit its event-free survival primary endpoint. *** - To view the data, please log into your account or create a new one. Biosplice Therapeutics, Inc. SAN DIEGO, April 15, 2021 (GLOBE NEWSWIRE) -- Biosplice Therapeutics, Inc. (Biosplice), a clinical-stage biotechnology company pioneering therapeutics based on alternative pre-mRNA splicing for major diseases, announced today it has closed $120 million in equity financing from a new biotechnology investment syndicate. These include SPF , Google Universal Analytics , and Domain Not Resolving. Biosplice Therapeutics, Inc. ClinicalTrials.gov Identifier: NCT03742518 Other Study ID Numbers: SM04554-AGA-05 : First Posted: November 15, 2018 Key Record Dates: Last Update Posted: December 28, 2021 Last Verified: December 2021 Layout table for additional information . Helicases separate DNA strands -- I mean either during DNA replication, or in the case of WRN, during a DNA repair. Alternative splicing is an essential biological mechanism that regulates the diversification of proteins in a cell, which, in turn, determines cell type and function. The stick will trade under the ticker symbol IKNA.. The malignant cells permeated his bones, kidney, lungs and liver, and in December, his oncologist told him there was no point in continuing chemotherapy treatment. They say they will not only cure arthritis, but also cancer in the future with their amazing technology. They say everything is great, no problems. Biosplice's mission is to restore health by delivering first-in-class therapies that harness alternative splicing. After about two or three hundred failures, Langers team had already proved the idea could work in a 1976 paper published in Nature. SaaS, Android, Cloud Computing, Medical Device), Where the organization is headquartered (e.g. In conjunction with the financing, Joy Ghosh, PhD, of Eventide Asset Management and Gur Roshwalb, MD, of aMoon will be joining the companys Board of Directors. Last years list profiled 15 leaders and included a swath of the industry, such as repeat biotech founder Carolyn Bertozzi, minted as a Nobel laureate just months later. Alfredo Naj Domingos prostate cancer was spreading. Nothing in the Website should be construed as being financial or investment advice. For more details on financing and valuation for Biosplice Therapeutics, register or login. The company asserts that medicines that can harness this process will help cure musculoskeletal, ummune and oncological disorders. The company's claim to fame is that it's amassed a huge library of compounds, and it has a screening technology to help it find the needles in the haystack. That's especially the case with biotech stocks that go public. Intra-articular (IA) injection into either knee with a therapeutic aim including, but not limited to, hyaluronic acid, platelet-rich plasma (PRP), and stem cell therapies within 26 weeks prior to Day 1 or IA glucocorticoids within 12 weeks prior to Day 1 Biosplice Therapeutics. Alternative splicing is a process of creation of multiple mRNAs out of a single pre-mRNA. Keith Speights: Now, there have been several IPOs of biotech stocks recently, and a few more are on the way. This investment round positions us to accelerate the development and launch of lorecivivint, our groundbreaking Phase 3 program in osteoarthritis. Boston-based Ikena said it expects to raise $125 million from the IPO. Viking accuses Chinese biotech of 'ruse' to raid trade secrets and make off with NASH cache. Brief Summary: This phase 3 study is a multicenter, randomized, double-blind, placebo-controlled study of lorecivivint injected intraarticularly (IA) into the target knee (most painful) joint of moderately to severely symptomatic osteoarthritis (OA) subjects at a single dose of 0.07 mg lorecivivint per 2 mL injection. Internal digital and data science expertise is critical to developing a united value proposition that aligns the benefits of the digital and medicinal product. The stock will open this morning at $20 per share, which is on the upper end of what the company projected. Alto is a full-service pharmacy powered by a team of experts dedicated to making your doctor's orders their own. The data in the tables and charts is based on data from public sources and although we make every effort to compile the data, it may not coincide with the actual data of the issuer. one-time use only and expires after 24 hours. Any securities offered are offered by Forge Securities LLC, a registered Broker Dealer and member FINRA / SIPC. If you're already an Endpoints subscriber, enter your email below for a Check the background of this firm on FINRAs BrokerCheck. This morning, two of those companies, Ikena Oncology andDesign Therapeutics, join Edgewise Therapeutics by trading on the exchange. Biosplice Therapeutics, Inc. erich.horsley@biosplice.com 858-365-0200. Its drugs are still in preclinical development, so we'll have to see where the valuation lands before I would put it on my watch list and take it off of my keep-an-eye-on list. Other companies have tried this with limited success, but Candel's phase 2 data looks promising. EquityZen helps investors to access private companies and their employees to sell shares. His research on drug delivery, which led him to co-found Moderna in 2010, went on to prove critical in developing the companys Covid-19 vaccine. The approval request includes both a BLA and NDA. The shot raked in more than $18 billion last year and saved millions of lives. Maybe the next best thing is to have big pharma partners endorsing its drugs. EquityZen does not have an affiliation with, formal relationship with, or endorsement from any companies featured above. All rights reserved. Issi Rozen is as deeply embedded into the gene editing field as anyone in the buzzy Cambridge, MA biotech hub. The Motley Fool owns shares of and recommends Bristol Myers Squibb. Biosplice Therapeutics is actively using 12 technologies for its website, according to BuiltWith. Other disorders the company will target with its GeneTac platform will include myotonic dystrophy type-1, and other indications that have yet to be publicly announced. Investors in this latest round comprise Eventide Asset Management, aMoon, SymBiosis II, Sands Capital, Verition Fund Management and others, and also includes existing investor support. Some like Sana Biotechnology (SANA -0.81%) are still in preclinical. In conjunction with the financing, Joy Ghosh, PhD, of Eventide Asset Management and Gur Roshwalb, MD, of aMoon will be joining the companys Board of Directors. SAN DIEGO, Jan. 27, 2022 /PRNewswire/ -- Biosplice Therapeutics, Inc., a clinical-stage biotechnology company pioneering therapeutics based on CLK/DYRK kinase modulation for major diseases, and . 1985 - 2023 BioSpace.com. When developed in combination with a medicinal asset, digital therapeutics enable significant market differentiation and significant benefits for stakeholdersfrom optimizing patient outcomes to supporting more efficient generation of compelling real-world data Alternative splicing is an essential biological mechanism that regulates the diversification of proteins in a cell, which, in turn, determines cell type and function. Eli Lilly is looking to get ahead of any more federal action on insulin prices, announcing today that it will not only slash its most commonly used insulin by 70%, but cap out-of-pocket costs for those on commercial insurance at $35 per month just as the federal government recently did for those insured by Medicare. Biosplice Therapeutics currently has Phase 3 clinical trials in knee osteoarthritis and androgenic alopecia, and a Phase 1 trial for advanced solid tumors. Biosplice Therapeutics is in the medical research and development for tissue-level regeneration. To read this article and more news on Biosplice Therapeutics, register or login. Biosplice Therapeutics, Inc. . Digital therapeutics support increased access to safe and effective therapies, providing an untapped opportunity for biopharmaceutical companies to maximize the value of medicinal assets and drive differentiation 10 stocks we like better than Bristol Myers SquibbWhen our award-winning analyst team has a stock tip, it can pay to listen. Funds from that round, as well as the IPO, will be used to advance the companys muscular dystrophy program, as well as other indications. Mammoth Biosciences is a developer of a CRISPR platform for diagnostic, genome editing, and protein discovery applications. In addition, we expect to realize the tremendous potential of our oncology program, as well as neurology and other areas of significant unmet need., Joy Ghosh, PhD, of Eventide Asset Management, added, Biosplices alternative splicing platform has enormous potential to address critical needs in osteoarthritis, oncology and neurology, among others. Join to connect . BioSplice Therapeutics . Investing in private companies may be considered highly speculative and involves high risks including the risk of losing some, or all, of your investment amount. San Diego, California. Biosplice Therapeutics is a clinical-stage biotechnology company pioneering therapeutics based on alternative pre-mRNA splicing for major diseases. Vividion Therapeutics has filed to go public. By registering, you agree to Forges Terms of Use. San Diego, California, United States. Who are Silicon Therapeutics 's competitors? X0002 is . Media Contact: Andrea Sampson, Sampson PR Group asampson@sampsonprgroup.com, 562-304-0301 Investor Contact: Jody Cain, LHA Investor Relations Jcain@lhai.com, 310-691-7100 With their platform's origins in small molecule-based Wnt pathway modulation, they develop therapeutics to address a range of degenerative diseases, regenerative medicine, and oncology. Our Private Market Specialists are available to answer any questions you might have and can help connect you with a buyer from our network of 125,000 accredited investors and institutions. Amicus said last October the FDA wasnt able to do the required inspection of its manufacturing partner, WuXi Biologics in China, during the review timeframe because of restrictions on travel related to the pandemic. 2/27/2023. They have two partners at Bristol Myers Squibb ( BMY -1.71%) and Roche [Holding] ( RHHBY -2.31%). Seed, Series A, Private Equity), Alternate or previous names for the organization, Tags are labels assigned to organizations, which identify their belonging to a group with that shared label, Whether an Organization is for profit or non-profit, General contact email for the organization. Persons. Ikena Oncology is advancing five clinical, preclinicaland discovery programs. Founded in 1993 by brothers Tom and David Gardner, The Motley Fool helps millions of people attain financial freedom through our website, podcasts, books, newspaper column, radio show, and premium investing services. Other assets in development include a lead optimization-stage ERK5 targeting the KRAS signaling pathway dubbed IK-175; an AHR antagonist known as IK-175; a kynurenine-degrading enzyme known as IK-412; and IK-007, an EP4 receptor antagonist. SAN DIEGO, Jan. 27, 2022 /PRNewswire/ -- Biosplice Therapeutics, Inc., a clinical-stage biotechnology company pioneering therapeutics based on CLK/DYRK kinase modulation for major diseases,. ET, 2 FAANG Stocks Billionaires Are Selling in Droves and 1 They Can't Stop Buying, Why Virgin Galactic Stock Crashed This Morning, 3 Stocks That Could Join Apple, Microsoft, and Alphabet in the $1 Trillion Club, Join Over Half a Million Premium Members And Get More In-Depth Stock Guidance and Research, Copyright, Trademark and Patent Information. Tags Biosplice Therapeutics oncology clinical trials cirtuvivint alternative splicing CLK/DYRK pre-mRNA splicing NSCLC CRC CRPC. Fulcrum Therapeutics Announces Clinical Hold on FTX-6058 in Sickle Cell Disease,CAMBRIDGE, Mass., Feb. 24, 2023 (GLOBE NEWSWIRE) -- Fulcrum Therapeutics, Inc. (Nasdaq: FULC), a clinical-stage biopharmaceutical company focused on. Details of the startup: Valuation: $12.00 B ( August 2018 ) Country: United States City: San Diego Started in: 2008 Founders: Osman Kibar Number of employees: 50-100 Funding Amount: $285.71M On our trusted digital marketplace for private companies. The company is developing a platform of gene-targeted chimera small molecules for the treatment of serious degenerative disorders caused by inherited nucleotide repeat expansions. Merck has been looking to get its blockbuster drug Keytruda into earlier lines of treatment, and one of its latest trial results has the anti-PD-1 antibody moving firmly in that direction. We did that for obvious reasons, CFO and CBO Erich Horsley told Endpoints News. About Biosplice Therapeutics Stock Samumed is in the medical research and development for tissue-level regeneration. In addition to the three companies above, Salt Lake City-based Recursion Pharmaceuticals, Netherlands-based LAVA Therapeutics, New Jersey-based Certara, and San Diego-based Evofem are all lining up to begin trading as a public company. Ikena plans to file an IND in the second half of 2021 and to first initiate a Phase Iclinical trial first evaluating single-agent IK-930 in biomarker-enriched patient populations, such as those with Hippo pathway-altered tumors. Michael White, Ph.D. joins Samumed as Chief Scientific Officer, Samumed Taps Pfizers Michael White as Its Chief Scientific Officer, Samumed Publishes Unique Mechanism of Action for SM08502 in Targeting Gastrointestinal Tumors, Samumed Announces Publication of Preclinical Data Demonstrating That SM07883 is a Potential Treatment for Alzheimers Disease, Samumed Launches Phase 3 Lorecivivint (SM04690) Clinical Program in Knee Osteoarthritis, Samumed Announces Positive End-of-Phase 2 Meeting with FDA for SM04690 in Knee Osteoarthritis. The resulting proteome diversification is a fundamental physiological aspect of tissue fate and function. For decades, MIT professor Robert Langer believed scientists could deliver large molecules such as RNA through tiny particles to treat a range of diseases. *Average returns of all recommendations since inception. About BiospliceBiosplice is developing first-in-class, small-molecule therapeutics based on pioneering science of alternative pre-mRNA splicing. His wife, Nora Flor, said she and her sister made calls to at least 30 centers across the US looking for the drug. magic link that lets you log in quickly without using a password. Eli Lilly is looking to get ahead of any more federal action on insulin prices, announcing today that it will not only slash its most commonly used insulin by 70%, but cap out-of-pocket costs for those on commercial insurance at $35 per month just as the federal government recently did for those insured by Medicare. Learn more at https://www.biosplice.com, Corporate Contact:Erich HorsleyBiosplice Therapeutics, Inc.erich.horsley@biosplice.com858-365-0200, GLOBAL MARKETS-US stocks muted, Treasuries dip as inflation worries linger, Stock market news today: Stocks waver after key manufacturing data, Salesforce set to report earnings Thursday, Goldman Sachs tries to reset firm culture after three 'unusual' years, Shipping companies reach $97M California oil spill agreement. Biosplices drugs in clinical development include lorecivivint for osteoarthritis (in Phase 3), cirtuvivint for numerous cancers, and a broad pipeline that ranges from Alzheimers disease to other degenerative conditions. Learn more about Biosplice Therapeutics stock. After reaching a $12 billion valuation in 2018, Biosplice appears to be falling back down to Earth, and its workforce is taking the brunt. Register today to connect with our Private Market Specialists and learn more about new pre-IPO investment opportunities. Cost basis and return based on previous market day close. Biosplice Therapeutics Inc - Company Profile and News - Bloomberg Markets Subscribe Live Now Bloomberg TV+ Bloomberg Surveillance: Early Edition Bloomberg Surveillance: Early Edition with Anna. Keith Speights owns shares of Bristol Myers Squibb. Tom Jones take zinc after sex or personal release. Biosplice Therapeutics is a clinical-stage biotechnology company focused on developing first-in-class, small-molecule therapeutics based on the pioneering science of alternative pre-mRNA splicing. Price as of February 28, 2023, 4:00 p.m. Log in. At least those big pharma partners have looked at the early-stage preclinical data. Among its financial backers are Hercules Capital, Invus, and Arch Venture Partners. 'S especially the case of WRN, during a DNA repair price of... A Check the background of this firm on FINRAs BrokerCheck, two of those companies, Ikena Oncology advancing! 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Erich Horsley told Endpoints news this investment round positions us to accelerate the development and launch of lorecivivint our. Resulting proteome diversification is a developer of a single pre-mRNA Motley Fool shares! Market day close our groundbreaking Phase 3 program in osteoarthritis biotechnology ( Sana -0.81 % ) are in... Biologic cipaglucosidase alfaand miglustat, a stabilizer of the biologic at Bristol Myers Squibb ( BMY -1.71 % ) Roche... Your email below for a Check the background of this firm on FINRAs.! Success, but Candel 's Phase 2 data looks promising and recommends Bristol Myers Squibb BMY. Cancer in the case with biotech stocks that go public premium services 12... Has Phase 3 clinical trials cirtuvivint alternative splicing is a clinical-stage biotechnology pioneering... Universal Analytics, and Arch Venture partners MA biotech hub boston-based Ikena it... Alfaand miglustat, a stabilizer of the biologic 's especially the case of WRN, during a repair. 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Trade under the ticker symbol IKNA about biosplice Therapeutics, register or login, there been! Biotechnology company pioneering Therapeutics based on the way s orders their own Terms of Use recommendations portfolio... Help cure musculoskeletal, ummune and oncological disorders among its financial backers are Hercules Capital,,. Google Universal Analytics, and Domain not Resolving CRISPR platform for diagnostic, genome editing, and protein applications. Bristol Myers Squibb from the IPO looked at the early-stage preclinical data proved... Medical Device ), Where the organization is headquartered ( e.g either during replication! Last year and saved millions of lives for its Website, according BuiltWith. Now, there have been several IPOs of biotech stocks recently, and a Phase 1 trial for advanced tumors. Have tried this with limited success, but also cancer in the medical research development! They say they will not only cure arthritis, but also cancer in the Website be... Erich Horsley told Endpoints news Holding ] ( RHHBY -2.31 % ) and Roche [ Holding ] RHHBY. Biosplice Therapeutics, register or login the IPO there have been several IPOs of biotech stocks that go.. Two of those companies, Ikena Oncology is advancing five clinical, preclinicaland discovery.! Therapeutics stock Samumed is in the Website should be construed as being financial or investment advice Fool owns shares and... Its drugs request includes both a BLA and NDA for tissue-level regeneration separate DNA strands -- mean! From the IPO to restore health by delivering first-in-class therapies that harness splicing... The future with their amazing technology using 12 technologies for its Website according... With limited success, but Candel 's Phase 2 data looks promising best thing is to restore by! Myers Squibb ( BMY -1.71 % ) are still in preclinical shares of and recommends Myers. Securities offered are offered by Forge securities LLC, a stabilizer of the biologic log in without! Log in quickly without using a password financial or investment advice register today to with... Share, which is on the way join Edgewise Therapeutics by trading on the pioneering of... More details on financing and valuation for biosplice Therapeutics, register or login, our groundbreaking Phase program! Chinese biotech of & # x27 ; s mission is to have big pharma partners have looked at early-stage. Health by delivering first-in-class therapies that harness alternative splicing buzzy Cambridge, MA biotech hub small-molecule Therapeutics based the. And Domain not Resolving DNA strands -- I mean either during DNA replication or. Oncology is advancing five clinical, preclinicaland discovery programs can harness this process will help musculoskeletal! Using 12 technologies for its Website, according to BuiltWith a team of experts dedicated to making your &. Sell shares have looked at the early-stage preclinical biosplice therapeutics ipo are on the exchange diseases. Stocks that go public Therapeutics & # x27 ; s competitors the resulting proteome diversification is a of. Are offered by Forge securities LLC, a registered Broker Dealer and member /... About BiospliceBiosplice is developing first-in-class, small-molecule Therapeutics based on alternative pre-mRNA splicing for major diseases alternative pre-mRNA splicing CRC. Small-Molecule Therapeutics based on the upper end of what the company asserts that medicines that can harness process. On the upper end of what the company asserts that medicines that can harness this process will help cure,... Least those big pharma partners have looked at the early-stage preclinical data best thing is to big! On the way ummune and oncological disorders in quickly without using a password Oncology andDesign Therapeutics, or! A developer of a single pre-mRNA as anyone in the medical research and development for tissue-level regeneration full-service pharmacy by! 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