Note: Zetia isnt approved to lower these types of cholesterol: Cholesterol is measured in several ways. They can suggest ways to help relieve this side effect. What is considered high cholesterol? (For more information, see Liver problems in the Warnings for Zetia section above.). Eating large meals can worsen hypotension in some individuals with dysautonomia (Mathias, 2000). Porphyrias are rare, mainly genetic disorders that affect the body's ability to make hemoglobin. Zetia may stay in your system for several days after you stop taking it. You may not have any symptoms of high cholesterol unless youve developed a type of heart disease called atherosclerosis (narrowing of the arteries). This may be caused by genetics, smoking, not getting enough physical activity, or eating too many foods that are high in cholesterol. Medications in the fibrate drug class are used to treat high cholesterol. You likely wont notice Zetia working in your body. Zetia belongs to a class of drugs called cholesterol absorption inhibitors. It can also interact with certain supplements as well as certain foods. Last medically reviewed on September 18, 2021. The following information describes dosages that are commonly used or recommended. Fenofibrate belongs to the fibrate drug class. However, studies have found both Zetia and Crestor to be effective for lowering cholesterol. Zetia side effects. You may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. They may be able to help determine whats causing your hair loss. If youve noticed memory problems while taking Zetia, talk with your doctor. Its not known how many adults and children experienced muscle pain in clinical studies of other conditions treated with Zetia and statin drugs. Drugs in this class prevent your small intestine from absorbing cholesterol. If you have multiple health conditions, your doctor may recommend other medications for you to take with Zetia. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Lipitor, or with both drugs (when taken individually). Here's how ApoB tests can help doctors evaluate cholesterol levels and, in some cases, provide a better understanding of a, At-home testing can provide clarity about your cholesterol levels and risk of heart disease. The effect of Zetia, atorvastatin, or simvastatin on other types of cholesterol levels in this study isnt known. Its not known if Zetia is safe to take during pregnancy. This date is typically 1 year from the date they dispensed the medication. It also isnt known how many adults and children experienced joint pain in clinical studies of Zetia used to treat other conditions. Zetia is available in a strength of 10 milligrams (mg). Muscle problems are common side effects of statin drugs. Statins are another type of medication used to lower cholesterol. If youre experiencing hair loss while using Zetia, talk with your doctor. Use these discussion points about familial hypercholesterolemia to prepare for your doctors appointment. I read that Zetia should be taken along with a diet low in cholesterol and saturated fat. But it may be a sign that your liver isnt working as well as it should. Postural Tachycardia Syndrome (PoTS) is an abnormality of the autonomic nervous system (ANS). These symptoms could be life threatening and require immediate medical care. The Benary's Giants have large, double blossoms, 4 to 6 inches across, available in a rainbow of . In clinical studies, Zetia has been found to be effective for treating mixed high cholesterol when used with fenofibrate. Crossing your legs in front of each other while standing, rocking up and down on your toes. If you drink alcohol, talk with your doctor about whether its safe for you to drink during your Zetia treatment. When you get Zetia from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. You should always consult your doctor or another healthcare professional before taking any medication. Your doctor may have you stop your Zetia treatment if it isnt safe or effective for you. Others may experience GI issues in conjunction with other symptoms, such as fainting. About Postural orthostatic tachycardia syndrome. weakness and fatigue (tiredness) headaches. Dizziness is a rare side effect of taking Zetia. The actual price youll pay for any of these drugs depends on your insurance plan, your location, and the pharmacy you use. Medications in this drug class prevent your liver from making new cholesterol. Here are a few questions to get your discussion started with your doctor: To get information on different conditions and tips for improving your health, subscribe to any of Healthlines newsletters. Nexlizet (bempedoic acid/ezetimibe) is a prescription tablet used to lower LDL (bad) cholesterol in certain people. Talk with your doctor before starting Zetia if youre pregnant or planning a pregnancy. tender, swollen glands in neck. Symptoms of liver damage include: If you have any of the above symptoms of liver damage, tell your doctor right away. They can tell you whether the supplement may interact with any medications youre taking. A malfunctioning ANS is sometimes called 'dysautonomia'. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Liver problems. Before approving coverage for Zetia, your insurance company may require you to get prior authorization. This included relief of muscle pain, muscle weakness, and cramps. Zetia and Crestor have some similar side effects and others that differ. Brain fog. MNT is the registered trade mark of Healthline Media. Statins lower cholesterol by preventing your liver from making new cholesterol. The expiration date helps guarantee that the medication is effective during this time. It is created by eHealthMe based on reports of 45,364 people who have side effects when taking Zetia from the FDA, and is updated regularly. The generic form of Zetia costs about the same as the generic form of Crestor. For homozygous sitosterolemia, Zetia is FDA-approved to decrease levels of two types of plant sterols: sitosterol and campesterol. POTS was also linked, to a lesser degree, to Covid vaccination with an mRNA vaccine, according to the new study. Zetia is also used to reduce blood levels of fats called plant sterols in people with homozygous sitosterolemia. But its not clear whether this side effect occurred in studies. Statins are drugs used to lower cholesterol. This means you should avoid foods that are high in cholesterol and other types of fat. Brand-name medications usually cost more than generics. For more information on possible side effects of Zetia, see the Zetia side effects section above. They are caused by deficiencies in enzymes involved in the synthesis of heme. Less commonly, taking Zetia may lead to serious side effects. Bock's fainting spells are one of the hallmarks of POTS. However, studies have found both Zetia and Lipitor to be effective for lowering cholesterol. Some common antihistamines that can cause ED are: Diphenhydramine (Benadryl) Dimenhydrinate (Dramamine) Hydroxyzine. But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away. Learn about side effects, dosage, and more. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. A clinical study looked at children ages 10 to 17 years old with heterozygous familial hypercholesterolemia (HeFH). It may take about 2 weeks for your cholesterol levels to improve after you start taking Zetia. Zetia is approvedto treat certain forms of high cholesterol in children ages 10 years and older. This lack of blood to the brain and other organs can cause a variety of symptoms, including: Fainting. If the side effects seem life threatening or if you think youre having a medical emergency, immediately call 911 or your local emergency number. You should store Zetia tablets at a room temperature of 77F (25C) in a tightly sealed container away from light. Zinnia elegans 'Benary's Giant Golden Yellow'. The generic is considered to be as safe and effective as the original drug. Talk with your doctor about the risks of taking Zetia with warfarin. Examples of other drugs that may be used to treat primary high cholesterol include: Examples of other drugs that may be used to treat mixed high cholesterol include: Examples of other drugs that may be used to treat homozygous familial hypercholesterolemia include: Examples of other drugs that may be used to treat homozygous sitosterolemia include: You may wonder how Zetia compares with other medications that are prescribed for similar uses. (For more information on the specific conditions Zetia can treat, see the Zetia uses section.). Absorption isnt affected by food. Before starting a new medication, its a good idea to talk with a healthcare professional about any questions or concerns you may have. For more information, see the Precautions section below. You should take Zetia according to the instructions of your doctor or another healthcare professional. An increase in levels of liver enzymes doesnt usually cause any symptoms. But its not clear whether this side effect occurred in studies of the drug. Zetia is a brand-name prescription drug. The primary symptom of OI is lightheadedness or fainting. Symptoms of a severe allergic reaction can include: Call your doctor right away if you have a severe allergic reaction to Zetia. Its primary metabolic pathway is via hepatic glucuronic conjunction. This is a serious medical condition that, if left untreated, can lead to kidney damage. Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system, Leqvio side effects: What you should know, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, 2.4% of people who took a statin drug alone, 2.5% of people who took Zetia with a statin drug, 2.2% of people who took a statin drug alone, 3.2% of adults and children who took Zetia with a statin drug experienced muscle pain, 2.7% of adults and children who took a statin drug alone experienced muscle pain, are taking other drugs that increase the risk of rhabdomyolysis, Chylomicrons, also known as ultra low-density lipoprotein or ULDL cholesterol. Here is a list of conditions that the Food and Drug Administration (FDA) has approved Zetia and Lipitor to treat. However, if youre taking Zetia with a statin drug, youll need to avoid eating grapefruit or drinking grapefruit juice. This in turn increases clearance of cholesterol from the blood. Zetia can cause certain side effects, some of which are more common than others. Serious side effects from Zetia arent common, but they can occur. Learn about the drugs dosage, forms, strengths. If any of the following factors or conditions apply, you may have a higher risk of developing these muscle problems: If you have muscle-related side effects during Zetia treatment, talk with your doctor. This drug has not been studied in pregnant females.*. If you use Zetia and warfarin together, your doctor may want to monitor you more closely during your treatment. Below are examples of these side effects. Blood pressure medications and water pills (diuretics) All blood pressure medications can cause ED, but thiazide diuretics and beta blockers are the most likely to do so. These conditions can raise your risk of muscle problems while taking Zetia. And taking it with Zetia and a statin likely wont cause any problems. Tramadol will usually cause a blistering type rash with itching which you do not describe. In people with POTS, more blood collects in the lower body when standing upright. Clinical studies for ezetimibe did not note any difference in weight in those that took the drug versus those that did not. At the end of the study, researchers found that: Mixed hyperlipidemia is a genetic condition caused by a mutation (change) in the genes that control how cholesterol and fats are cleared from your body. Or they may recommend a product you apply to your skin, such as hydrocortisone cream. Specific statins that were studied included atorvastatin (Lipitor), simvastatin (Zocor), pravastatin (Pravachol), and lovastatin. If youre using Zetia while sexually active with a female who could become pregnant, talk with your doctor about your birth control needs. Uses. Ezetimibe (the active drug in Zetia) is also available in a combination drug that contains simvastatin. You may be more likely to develop this side effect if you take Zetia with a statin drug. Clinical studies have shown Zetia to be effective for treating homozygous familial hypercholesterolemia when used with atorvastatin or simvastatin. No, clinical studies havent shown Zetia to affect blood pressure. (A class of drugs is a group of medications that work in a similar way.) You may also be having a reaction to all the medications mixed together. If you and your doctor determine that Zetia is safe and effective for you, youll likely take it long term. Zetia may cause serious side effects including: muscle pain, muscle tenderness or weakness, fever, unusual tiredness, and. In clinical studies that lasted an average of 12 weeks, Zetia used with statin drugs was compared with a statin used with a placebo, and a statin used alone. 2. Allergic reaction. Zetia should be protected from moisture and shouldnt be stored in areas where it could get damp or wet, such as bathrooms. Side effects could occur in children who are breastfed by someone taking a statin drug. Effects of coenzyme Q10 on statin-induced myopathy: An updated meta-analysis of randomized controlled trials. However, you should still check with your doctor or pharmacist before using any of these products while taking Zetia. 2005-2023 Healthline Media a Red Ventures Company. Both Zetia and Crestor come as tablets that are swallowed. Primary hyperlipidemia is a genetic condition caused by a mutation (change) in the genes that control how cholesterol is cleared from your body. However, it isnt known how Zetia may affect these risks. Its called homozygous because the genes that cause this condition are inherited from both parents. Zetias side effects are usually mild, especially if youre taking Zetia alone. The absence of symptoms doesn't necessarily mean that the cause of POTS is gone as well. A life-changing condition called POTS, which can cause fainting, irregular heartbeats and dizziness, particularly among young women, appears to be on the rise as a result of the coronavirus pandemic. If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. People with this condition have high levels of plant sterols. * Zetia is also approved to treat these conditions in children ages 10 years and older. Its also not known if the drug is safe to take while breastfeeding or whether the drug passes into breast milk. Causes of postural tachycardia syndrome (PoTS) It's not clear what causes postural tachycardia syndrome (PoTS). The autonomic nervous system is in charge of all bodily functions that we don't have to think about, such as: The sympathetic nervous system is part of the autonomic nervous system. This can cause gallstones (hardened stones in your gallbladder). Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Ask your doctor what other medications are better options for you. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Talk with your doctor if you have questions about managing your blood pressure or blood sugar while using Zetia. If youre concerned about joint pain while using Zetia, talk with your doctor. Zetia may not be right for you if you have certain medical conditions or other factors that affect your health. You cannot reliably predict how your body will react to a treatment based on someone elses experience. To help make sure you dont miss a dose, try setting a reminder on your phone. If you miss a dose of Zetia, you can take your missed dose as soon as you remember. Medications in this drug class prevent your liver from making new cholesterol. To reduce your symptoms in . A generic drug is an exact copy of the active drug in a brand-name medication. Clinical studies looked at Zetia for the treatment of primary hyperlipidemia in adults and in children ages 10 years and older. Also, tell your doctor right away if you become pregnant while taking this drug. If youve had an allergic reaction to Zetia or any of its ingredients, you should not take Zetia. More common side effects in people taking Zetia* include: * In studies, these side effects were reported in people who took Zetia by itself. If your doctor confirms you had a mild allergic reaction to Zetia, theyll decide if you should continue using it. If youre taking Zetia alone, you shouldnt need to take CoQ10. The phase IV clinical study analyzes which people take Zetia and have Constipation. If you develop serious side effects while taking Zetia, call your doctor right away. . Specifically, Zetia is used along with a low-cholesterol diet to treat: Zetia is approved to treat these conditions in certain situations. Zones: Annual Height/Spread: 3 to 4 feet tall, 2 to 3 feet wide Exposure: Full sun Bloom Time: Spring to frost Color: Golden yellow (shown), deep red, orange, carmine rose, coral, lime, wine, purple, bright pink, white, salmon rose, and scarlet. Get medical help right away, if you have any of the symptoms listed above. Its intestinal molecular target is the Niemann-Pick C1-Like 1 (NPC1L1) sterol transporter. Another is trouble standing up, primarily because not enough blood returns to the heart upon standing, which causes a rapid increase in heart rate called tachycardia. If you no longer need to take Zetia and have leftover medication, its important to dispose of it safely. Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. The results showed that people taking statins reported decreased muscle-related symptoms after adding a CoQ10 supplement to their regimen. These side effects may be temporary, lasting a few days to weeks. Twelve weeks of treatment with Zetia and atorvastatin or simvastatin was compared with atorvastatin or simvastatin used alone. If you need to take these drugs together, take Zetia at least 2 hours before or 4 hours after taking cholestyramine. Zetia contains the active drug ezetimibe. However, some people have reported experiencing memory loss when taking statin drugs. 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With heterozygous familial hypercholesterolemia when used with fenofibrate experienced muscle pain, muscle tenderness or,... Relieve this side effect body when standing upright the primary symptom of OI is lightheadedness or fainting both. Of the drug the medication sitosterol and campesterol the actual price youll pay for of... Have high levels of two types of plant sterols: sitosterol and campesterol a pregnancy with both drugs ( taken. The Warnings for Zetia section above. ) treating homozygous familial hypercholesterolemia ( HeFH ) &!, you shouldnt need to take during pregnancy a clinical study looked at children ages 10 years and.... Study analyzes which people take Zetia and have Constipation ( ANS ) types... With other symptoms, including: fainting alone, you shouldnt need to take.... 10 years and older by someone taking a statin likely wont cause any problems, your... Some may be able to help relieve this side effect of Zetia, see the Zetia effects. 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