But Oklahoma has held each of its five opponents to 100 rushing yards or fewer. It may not be the season that head coach Nick Saban drew out, but a win against LSU this weekend will give the Tide more momentum. ET. ET: Boston College 27, Duke 24, Kentucky at Missouri, Noon ET: Kentucky 31, Missouri 23, Minnesota at Nebraska, Noon ET: Minnesota 26, Nebraska 18, Iowa at Purdue, Noon ET: Purdue 23, Iowa 17, Western Kentucky at Charlotte, Noon ET: Western Kentucky 31, Charlotte 14, Maryland at Wisconsin, Noon ET: Maryland 28, Wisconsin 27, Georgia Tech at Virginia Tech, 12:30 p.m. Ole Miss trailed Alabama 35-0 before making the final score (42-21) a little bit more respectable. 1 team in the country at home next week, but a road win in Baton Rouge is more important this weekend. UCLA dominated Washington in a Friday night game in Los Angeles to improve to 5-0 and earn a top-25 ranking. Although Kentucky suffered its first loss of the season to Ole Miss last week, the Wildcats' chances of winning the SEC East are still in front of them. In 2019, No. UNC's Week 4 loss to Notre Dame knocked the Heels out of the rankings, but this is still a quality 4-1 team. Following the Oregon loss, BYU defeated Wyoming and a 1-3 Utah State team in the last two weeks. Kansas won in a Week 2 shootout against West Virginia, winning 55-42 in overtime. USC at UCLA pick: The computer favors Southern Cal by a 60.5 percent margin over the rival Bruins to stay in the Pac-12 title hunt, but watch . The Buckeyes need to be dominant in this matchup to continue to show the selection committee just how good they are, and they'll be exactly that. ET: TCU's defense has allowed at least 32 points and more than 400 yards of total offense in three consecutive games against Cal, SMU and Texas. Week 6. Circa Sports reopened its conference future odds ahead of Week 6 with six different ACC teams at 8-to-1 or less to win the title Clemson at +180 (risking $1 to win 41.80), Pittsburgh at +470 . There were a few bad beats, but I can't describe my picks as anything other than terrible last week. ET. The Scarlet Knights started out 3-0, played well in a loss at Michigan and now they get to host a Michigan State team that, despite a 5-0 record, has left much to be desired on defense. ET. 2 Georgia on Saturday. Free $60 Account Today's Best Bet service@docsports.com There aren't a lot of big-time matchups, but some wild ones are upcoming. ET, ESPN) Florida . No. 8). But I think Martinez can make some plays with his feet late in this one to win it close. 13 Kentucky vs. South Carolina, 7:30 p.m. Penn State hasn't beaten OSU since 2017, and Michigan defeated the Nittany Lions 21-17 last season. If Sanders is able to suit up against Kansas, the Cowboys will leave town with a victory, but it's a toss-up if Daniels is back in the lineup. The two combined for 382 total yards and four touchdowns in the win over Arkansas last week. NCAA football predictions and Week 6 Opening Line Report with Best Bets and Picks by expert college football handicappers at Docsports.com. But Indiana has dropped their last two games against Cincinnati and Nebraska, losing both games by at least two scores. ET: UTSA 26, UAB 19, Navy at Cincinnati, 4 p.m. Despite losing 49-3 in Week 1 to Georgia, the Ducks have rebounded nicely and are 4-1. Fifth-year senior quarterback Devin Leary leads NC State's offense. But Kansas is facing a very good TCU team. And this Arkansas defense has been every bit as stingy as Alabama's thus far this year. But what he did against LSUrepeatedly running around like a chicken with its head off before pulling some magical play out of nowherealmost certainly isn't going to fly against this Georgia defense. The Aggies suffered a shocking upset at home to Appalachian State in Week 2, and lost 42-24 to Mississippi State last week. Ole Miss should have no problems winning this one, even on the road. Photo by Steph Chambers/Getty Images The reigning Heisman winner left last week's Arkansas game in the second quarter with a sprained shoulder. It was incredibly cool to see Key, who played at Georgia Tech from 1997 to 2000, get an upset victory in his first game as interim head coach. ET. They have gone a combined 1-3 over the last two weeks, but a rivalry like this one will always have some juice. ET. However, the Cowboys have been rock-solid on defense, limiting opponents to 304.0 total yards per game. California started the season with some solid showings, but now it is riding a four-game losing streak, all of which came against Pac-12 opponents. Instead, OSU-Rutgers looked an awful lot like the "very good team against very bad team" matchup we've grown accustomed to watching in recent years. Vanderbilt's defense checks in at 114th in scoring defense nationally. And in each of the past two seasons, he racked up more rushing yards against Virginia than he did against any other foe. ET: Tulsa 38, Navy 17, Ball State at Central Michigan, 3:30 p.m. LSU can't run the ball. ET: UConn-Vanderbilt was on ESPNU this past weekend, and it actually ended up producing one of the most entertaining fourth quarters of the day, ending on a game-winning field goal for the Commodores at the buzzer. I like Oklahoma State at home here. Thus, Wake Forest's entire defensive game plan in this one should be containing mobile quarterback Garrett Shrader and star running back Sean Tucker. ET, UTSA (5-0) at Western Kentucky (1-3), 7 p.m. No. Tennessee caught a break for its trip to Baton Rouge, Louisiana. ET: UTEP 27, Rice 23, Appalachian State at Coastal Carolina, 7:30 p.m. The Jayhawks moved to 5-0 after beating Iowa State 14-11 last week. Week 6 college football picks, bold predictions led by Iowa-Penn State, SEC showdowns. 13 Arkansas vs. No. Kansas will play host to College GameDay for the first time in program history as it attempts to go to 6-0 . They get a tough test of their own at the Rose Bowl against the Utah Utes. Although Clemson is the overwhelming favorite to win the ACC, the ACC Coastal is still very much up for grabs. Let's start with a quick recap of Week 7 of NCAAF, as there were major shifts in the power . 20 Kansas State (-2.5) at Iowa State (7:30 p.m. 25 San Diego State (4-0) vs. New Mexico (2-3), 9 p.m. 21 Texas (4-1) vs. No. The Midshipmen have averaged 45.8 points against the Mustangs, and they enter this contest right after a 34-30 win over UCF in which they rushed for 348 yards and three touchdowns. 2021 Week 6 Matchups. Texas A&M lost its chance to claim that with a loss to Mississippi State in Week 5 and it will likely lose on Saturday against Alabama. Penn State has lost two of its last three games, which is discouraging, but the recent competition has been fierce. 14 Notre Dame (4-1) at Virginia Tech (3-1), 7:30 p.m. Beating South Carolina will help them take the next step in that goal. ET. Prediction:San Diego State 41, New Mexico 13, No. We will have 6 more Premium Picks against the spread this week! 17 TCU . Dimers has free College Football picks, College Football predictions today and College Football computer picks for every game of the NCAA Football regular season and postseason. 25 LSU (noon ET, ESPN), No. It is allowing just 8.9 points and 75.6 yards on the ground. They've put up at least 40 points seven times during this streak, as well. The Horned Frogs can afford a high concession or two because their offense is averaging 549.5 total yards per game, which is 129 yards above Kansas' average. Kansas State is fresh off a 48-0 win against the Cowboys, but they weren't at full strength. A bye for 'Cuse comes before a tough schedule ahead, including games vs. NC State, at Clemson and vs. Notre Dame for the rest of the month. Let's get back on the right track. Since his firing, the Sun Devils are 0-2 with losses to Utah and USC. Here is the full slate of this week's games with predictions for each. ET. If Ewers and Gabriel don't play, both offenses will likely rely on their run games. 24 Pitt 26-21 last weekend. The Bruins vaulted into the Top 25 after beating then-No. They're set to face an SEC opponent, and although Arkansas isn't at the top of the conference, the Flames don't have the talent to beat the Razorbacks in Fayetteville. ET: Northern Illinois 27, Central Michigan 18, Western Michigan at Bowling Green, 7 p.m. Week 6 of college football looks to continue a chaotic season filled with upsets and surprises. I think this Yellow Jacket team can rally behind him and give him his second win, this time at home. 21 Minnesota 20-10. With Adrian Martinez playing as well as he has been over the past five weeks, this is going to be the stiffest resistance Michigan's defense has faced thus far. ET: Appalachian State 32, Coastal Carolina 17, UMass at UConn, 7 p.m. 18 UCLA (3:30 p.m. "Stanford Steve" Coughlin and Chris "The Bear" Fallica cover the college football season as only they can, offering their top picks, betting nuggets and totals worth wagering on. ET: USC's season has oscillated back and forth between "Win by at least 23 points" and "get embarrassed on defense in a loss by double digits." ET: Middle Tennessee 21, Louisiana Tech 13, Washington State at Stanford, 3:30 p.m. In the exception to that rule, though, Texas scored 70 and ran all over the Red Raiders, so it wouldn't be much of a surprise if Zach Evans has a field day for TCU. ET: San Jos State 17, Colorado State 10, Hawai'i at Fresno State, 10:30 p.m. Arizona State is searching for its next head coach, while UCLA is back near the top of the college football world. Prediction: Illinois 24, Michigan State 16. The Wolfpack would be booted from the Top 25 if they're dominated by the Demon Deacons at home. 21+ (18+ NH/WY). 3 Penn State 24-23 on a last-second field goal. But the combination of Arizona State's above-average secondary and Stanford's considerably-below-average run defense should keep another upset from happening. It's been a rough three weeks for the Nittany Lions, but it's been a rough year for the Hoosiers. 7 Oklahoma State (-10) (3:30 p.m. Arizona State is back in the AP Top 25 after a 42-23 road win over then-No. It looks like Ducks quarterback Bo Nix is feeling comfortable in Dan Lanning's offense. Jalon Daniels, who has had 11 touchdown passes in four weeks, threw for just 93 yards on 14 pass attempts. Under interim head coach Brent Key, who was promoted from offensive line coach, Georgia Tech went on the road and upset No. But Arkansas had two long passing touchdowns en route to 448 total yards in Week 4 and Mississippi State threw for more than 400 yards this past weekend. If the turnover margin in this one ends up being a wash, I like Penn State to get the road win, as I have substantially more faith in the Nittany Lions offense in a battle of field position. Week 6 of the college football schedule is here, and it's time to make our picks and predictions for the top games on Saturday. James Parks. Fresh off a seven-turnover masterpiece against Maryland, Iowa has a nation-best turnover margin of plus-12. It was surprising, given that Georgia's offense scored 30 or more points in each game prior. 16 Penn State at Indiana, 3:30 p.m. ET (Friday)Charlotte 28-21, West Virginia (2-3) at Baylor (4-1), Noon ETBaylor 24-17, South Carolina (3-2) at Tennessee (3-2), Noon ETTennessee 35-20, Akron (1-4) at Bowling Green (2-3), Noon ETBowling Green 28-14, Northern Illinois (3-2) at Toledo (3-2), Noon ETToledo 31-17, Georgia Tech (2-3) at Duke (3-2), 12:30 p.m. ETGeorgia Tech 31-27, Old Dominion (1-4) at Marshall (2-3), 2 p.m. ETMarshall 42-13, Florida State (1-4) at North Carolina (3-2), 3:30 p.m. ETNorth Carolina 45-21, Wisconsin (1-3) at Illinois (2-4), 3:30 p.m. ETWisconsin 24-17, Central Michigan (2-3) at Ohio (1-4), 3:30 p.m. ETOhio 28-27, Miami-Ohio (2-3) at Eastern Michigan (3-2), 3:30 p.m. ETEastern Michigan 35-24, Ball State (2-3) at Western Michigan (4-1), 3:30 p.m. ETWestern Michigan 35-24, Middle Tennessee (2-3) at Liberty (4-1), 3:30 p.m. ETLiberty 34-20, San Jose State (3-2) at Colorado State (1-3), 3:30 p.m. ETSan Jose State 27-23, Florida Atlantic (3-2) at UAB (3-2), 3:30 p.m. ETUAB 28-17, North Texas (1-3) at Missouri (2-3), 4 p.m. ETMissouri 45-21, East Carolina (3-2) at UCF (2-2), 6 p.m. ETUCF 35-31, UTSA (5-0) at Western Kentucky (1-3), 7 p.m. ETUTSA 34-31, Georgia Southern (2-3) at Troy (2-3), 7 p.m. ETGeorgia Southern 28-24, Buffalo (2-3) at Kent State (2-3), 7 p.m. ETBuffalo 31-27, South Alabama (3-1) at Texas State (1-3), 7 p.m. ETSouth Alabama 28-21, UTEP (4-1) at Southern Miss (1-4), 7 p.m. ETUTEP 24-21, Georgia State (1-4) at Louisiana-Monroe (2-2), 8 p.m. ETGeorgia State 27-20, Memphis (3-2) at Tulsa (1-4), 9 p.m. ETTulsa 35-28, New Mexico State (1-5) at Nevada (3-1), 10:30 p.m. ETNevada 45-10, UCLA (3-2) at Arizona (0-4), 10:30 p.m. ETUCLA 31-21. 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