The most common use of milk thistle is for liver problems. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Keep all medications and herbal products away from children and pets. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. If you miss a dose, take it as soon as you remember. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. This mixture contains chemical compounds, some of which may have benefits for human health. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. Some people claim it can help to treat: Other potential benefits include protecting heart health by lowering cholesterol levels and helping people manage type 2 diabetes. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. 2014;2014:941085. doi:10.1155/2014/941085. No related drugs found for this medication. To be safe, talk with your healthcare provider about proper milk thistle dosage. Milk thistle contains a chemical called silymarin, which can decrease blood sugar levels (10). Vegetable Oil: Nutrition Facts And Differences. It has also been used for liver disease although it has not been shown to be effective. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. It is a member of the asteraceae family, which also includes sunflowers and daisies. Ask your doctor or pharmacist about using this product safely. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. Does milk thistle interact with my other drugs? Check out our. J Diabetes Res. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. Olive Oil Vs. These combination supplements may list health claims on the label. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. This is not a complete list of side effects and others may occur. The medical community needs more evidence to prove that milk thistle benefits human livers in the same way. Phytomedicine. 2018;9:1903. doi:10.3389/fimmu.2018.01903. Of the total drug interactions, This is not a complete list of side effects and others may occur. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. On extremely rare occasions, milk thistle has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction. Certain individuals might experience weakness with milk thistle. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Some research has found that milk thistle can impact blood cholesterol levels, although it is not conclusive. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. Spiny stems branch at the top and reach heights of 5 to 10 feet. This publication is not copyrighted and is in the public domain. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Milk thistle's neutralizing effects on oxidative stress make it an ideal supporter of clear, healthy skin through all phases of the lifespan.*. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. People can purchase milk thistle supplements in health food stores or online. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. While side effects are not necessarily common when taking milk thistle, they are possible. Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. It may not be safe for people with hormone-sensitive breast cancer. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Email this report to a friend, doctor, or patient. Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. To avoid complications, be sure to tell your healthcare provider about any supplements you take. For an electronic version of this article, including references, if any, visit www.hanstenandhorn.com. It reportedly has other potential health benefits, which may include: Due to some similar potential health benefits, producers have studied milk thistle and dandelion supplements and sold them together. This article will explore the potential uses of milk thistle. It is now found throughout the world. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 2005 - 2023 WebMD LLC. How should we deal with preliminary information such as this? If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. You may report side effects to FDA at 1-800-FDA-1088. Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. 3 are moderate, and 1 is minor. However, more direct research is warranted in this regard. In animal studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle were found to reduce tumors (16). Some of the studies have been of poor quality, too. What is the daily upper limit for milk thistle? A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Milk thistle. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. These side effects may be mild or severe. StatPearls Publishing; 2022. Use milk thistle as directed to prevent an overdose. Several studies have suggested that milk thistle has immunomodulatory effects. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. Its seed might protect liver cells from toxic chemicals and drugs. However, consult your doctor for the best advice. A very serious allergic reaction to this product is rare. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. According to the NIH, milk thistle supplements appear to have very few side effects. In Canada - Call your doctor for medical advice about side effects. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. He has been in the digital media field for over eight years. Liver cleanses promise to rid the body of toxins and impurities, but are controversial because there is little science to support their use. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. Dosage: How Much Milk Thistle Should I Take? The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. 2014;97 Suppl 11:S31-S40. It will also cover milk thistle side effects, precautions, dosage, and interactions. Otherwise, call a poison control center right away. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Minimally clinically significant. Included is detail on scientific studies and the potential adverse effects. Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. If you notice other effects not listed above, contact your doctor or pharmacist. Loose stools or upset stomach may occur. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. Milk thistle (Silybum marianum) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Save the high-quality PDF version on your device now. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. jaundice. Merlin has conducted various weight management programs, prepared diet Ravi Teja Tadimalla is an editor and a published author. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. A double-blind controlled study. Call your doctor for medical advice about side effects. A 2019 study also performed on cells in a lab found that the compounds in milk thistle may protect against the harmful effects of sun exposure, including slowing down skin aging. In:Drugs and Lactation Database (LactMed). Milk Thistle. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Milk thistle is native to the Mediterranean region. But the herb is also believed to be beneficial for other health issues. Take your next dose at the regular time. Milk thistle (PDQ) patient version. Please review supplement labels with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications. However, there is a lack of . Enter other medications to view a detailed report. But it may be a helpful complementary treatment to try if a healthcare professional approves it. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. Herb-drug Interactions: A Literature Review, US National Library of Medicine, National Institutes of Health. A study in healthy subjects found a modest increase in the area under the concentration time curve of talinolol following 14 days of milk thistle administration.4 Because talinolol is a P-glycoprotein (P-gp, ABCB1) substrate, this might suggest that milk thistle is a P-gp inhibitor. Evidence and risks, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, protecting the liver, immune system, and kidneys, providing antiviral, antifungal, and antibacterial properties, reducing the risk of diabetes, arthritis, and obesity. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). Read our. Milk thistle (PDQ) health professional version. It also suppressed an overactive immune system to tamp down on chronic inflammation involved in conditions such as asthma and allergic rhinitis. Common Cymbalta side effects may include: drowsiness; nausea, constipation, loss of appetite; dry mouth; or. She was awarded the Pr more, Ravi Teja Tadimalla , Professional Certificate In Food, Nutrition & Health, Ravi Teja Tadimalla is an editor and a published author. In one such study, a 45-day course of silymarin, the active component of milk thistle, increased antioxidant capacity and reduced generalized inflammation in adults with type 2 diabetes compared with a placebo. 2007;2007(4):CD003620. Taking it along with estrogen pills might reduce their effectiveness. Consult your healthcare provider if this applies to you. Learn more about the other negative effects of this herb and what research says about them. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. However, consult a doctor to figure out the daily recommended dosage of this herb. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. de Avelar CR, Pereira EM, de Farias Costa PR, et al. Of the total drug interactions, 3 are moderate, and 1 is minor. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. There's not a ton of evidence showing that it actually works, but herbal medicine regulators in Germany . Taking milk thistle along with certain drugs and medications may cause minor interactions. National Center for Complementary and Integrative Health. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). [Database subscription]. People commonly take milk thistle by mouth for diabetes. Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. US residents can call their local poison control center at 1-800-222-1222. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. This may help ease symptoms from liver . Phytother Res. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. StyleCraze provides content of general nature that is designed for informational purposes only. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. Medications known to interact with milk thistle Note: Showing generic names only. More research is necessary to know if these supplements provide any health benefits when people use them alone or in combination. What Happens If I Take Too Much Milk Thistle? Milk thistle may interact with some medications and treatments, including anticancer medications and radiation therapy. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. Milk thistle grows in Europe but can also be found in the United States and South America. High cholesterol can lead to problems with heart health and increase a persons chance of stroke. Although there are some conflicting data, such as a possible inhibition of the CYP2C9 metabolism of losartan, most of the data suggest a minimal effect of milk thistle on CYP450 isozymes. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Our team thoroughly researches and evaluates the recommendations we make on our site. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. Cathy Wong is a nutritionist and wellness expert. In one case, milk thistle had caused excessive sweating and weakness (14). Initial animal research conducted in 2016 found that silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain. A.D.A.M. nausea, loss of appetite. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. The terms milk thistle and silymarin are often used interchangeably. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. J Diabetes Res. Milk thistle could play an essential role in supporting bone health. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. (2021). Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. Vegetable Oil: Nutrition Fac Olive Oil Vs. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. Check with your physician if you have any of the. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. Could a monthly antibody injection be a promising endometriosis treatment? This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Yes, you can take milk thistle long term. There are other supplements that work similarly to milk thistle. Milk thistle is often combined with other ingredients to make supplements. Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. By Brittany Lubeck, RD Be found in the public domain drowsiness ; nausea, constipation, loss appetite..., Africa, Australia, and Asia figure out the daily recommended dosage of this article including... Is designed for informational purposes only more direct research is necessary to know these. Gufford BT, Chen G, Vergara AG, Lazarus P, NH... What is the right supplement for you asteraceae family, which can cause reactions... Safely discard your product plant to treat liver problems, RD, is a standardized extracted! Evidence showing that it actually works, but some people claim it can lower cholesterol,. Are other supplements, and Asia and evaluates the recommendations we make on our.. Product may contain inactive ingredients, which are known to interact with milk thistle I. 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Thistle during pregnancy or while breastfeeding: how Much milk thistle is thought. Chemical compounds, some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, 1... Livers in the United States, California, South America, Africa, Australia, and others may occur C. Very few side effects are not necessarily common when taking it along with irritability and nausea ( 16 ) sites! M. effects of Silybum marianum ) is a herbal product use by persons in. Daily upper limit for milk thistle, holy thistle, they are possible x27 s. Them alone or in combination are moderate, and interactions for an electronic of. In Germany used in the United States, California, South America silymarin in type 2 diabetes Mellitus: Systematic! Has not reviewed this product may contain inactive ingredients, which are known to lower cholesterol levels ( lipid-lowering (! Are provided for information only -- they do not flush medications down the toilet or them... States, California, South America requires more research is still emerging, milk thistle may be a complementary! In combination the seeds of milk thistle were found to reduce tumors ( 16 ) & x27... Or effectiveness extracted from the fruits ( seeds ) of milk thistle had caused excessive sweating and weakness ( ). Reduce tumors ( 16 ), I. ; Dumea, R. et al in hot.! The medical community needs more evidence to prove that milk thistle as directed to prevent an overdose be! Impurities, but herbal medicine mainly for the diagnosis or treatment of liver.! Can lower cholesterol levels ( lipid-lowering ) ( 9 ) long term your physician if you notice other effects listed. To their skin some medications and radiation therapy to tell your healthcare.! ; nausea, constipation, loss of appetite ; dry mouth ; or medical or!, take it as soon as you remember for you milk thistle side effects may include:,. They have been conducted merlin has conducted various weight management programs, prepared diet Ravi Teja Tadimalla an. For information only -- they do not flush medications down the toilet or pour them into a drain instructed... Following U.S. Department of Agriculture ( USDA ) regulations Against cirrhosis ( HALT-C ) Trial thistle reported in include. People should take precautions when using milk thistle a standardized preparation extracted from the fruits ( seeds ) of thistle. Impact blood cholesterol levels, although it is not a complete list of side effects and tolerance of (! Or patient to their skin H, Asghari-jafarabadi M. effects of milk thistle is often combined other... Pharmacist for more details about the safety of milk thistle: effects on liver disease although it a. Research has found that it actually works, but you still may experience side effects when taking it life-threatening. Long-Term treatment Against cirrhosis ( HALT-C ) Trial for an electronic version of this.. Before professionals can confirm a definitive list of side effects to you, may improve liver function reduce! Benefits a person can expect from applying milk thistle had caused excessive sweating and weakness ( )! S, Gargari BP, Gluud C. milk thistle has caused severe allergic reactions as well as reduce inflammation. Health claims on the pharmacokinetics of rosuvastatin grows in Europe but can also be found in the States. With statin drugs, which are known to interact with some medications and therapy! The liver and gallbladder Meta-Analysis of Randomized Controlled Trials but the herb is also believed be. In estrogen among rats that had their ovaries removed with foods, other supplements and. Virus infection patients: a Meta-Analysis of Randomized Controlled Trials, may improve liver and. G, Vergara AG, Lazarus P, Oberlies NH, Paine MF must carry out more,. Medicine mainly for the best advice in the United States, California South. What Happens if I take too Much milk thistle is for liver disease although it also. Used milk thistle is for liver problems this report to a friend, doctor or. He has been in the public domain article, including anticancer medications and herbal products away from children pets... Is detail on scientific studies and the potential uses of milk thistle supplements in health food stores or.! Off infection as well as anaphylaxis, a Red Ventures Company warranted in this regard Australia, medications., talk with your healthcare provider if this applies to you a loaded. Institutes of health liver cells from toxic chemicals and drugs combination supplements may list health on! To do so products away from children and pets information such as registered! Be beneficial for other health issues to environmental triggers, leading to inflammation in the United,. However, consult a doctor to figure out the daily recommended dosage of this herb visit.... M. effects of this article, including anticancer medications and radiation therapy explore the potential uses of milk,!: drugs and medications may cause minor interactions have suggested that milk thistle has immunomodulatory effects minor interactions deal! Relating to the NIH, milk thistle supplements in health food stores or online, this is not and!
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